Lymphoma which chemotherapy protocol and why

For some types of lymphoma, other drugs are given either alone or with chemotherapy. This is sometimes the case with:. Patients will be closely monitored while getting chemotherapy and any changes or side effects should be discussed with the medical team.

Chemoimmunotherapy is chemotherapy combined with immunotherapy. Chemotherapy uses different drugs to kill or slow the growth of cancer cells. Immunotherapy uses treatments to stimulate or restore the ability of the immune system to fight cancer. Treatment affects each person differently — even the same treatment can have different side effects for each patient. The doctor or chemotherapy nurse should discuss the side effects with the patient.

It is important to try to maintain the highest tolerable dose during chemotherapy treatment. Studies have shown that reducing the dose or delaying chemotherapy treatments until side effects subside may decrease the likelihood of remission and the chances for long-term survival in some types of lymphomas.

It is important for someone receiving chemotherapy to understand that changing the dose or treatment cycle to reduce short-term side effects may be harmful in the long run. However, quality of life is valuable as well, and patients need to decide whether the side effects are tolerable or not. It is important to make this decision in an informed way and understand the potential consequences of your choice. Close Menu. About Lymphoma What is Lymphoma?

What is the lymphatic system? What is the immune system? Symptoms of Lymphoma Possible causes of lymphoma? About Lymphoma. As a single agent for the treatment of adult patients with relapsed or refractory mantle cell lymphoma MCL. Monotherapy for the treatment of adult patients with follicular lymphoma FL that is refractory to two prior lines of treatment.

As monotherapy is indicated for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma cHL after autologous stem cell transplant ASCT and treatment with brentuximab vedotin.

Obinutuzumab maintenance therapy is indicated in patients with follicular lymphoma FL who have responded to induction treatment with obinutuzumab and chemotherapy CHOP, CVP or bendamustine or have stable disease. Obinutuzumab in combination with bendamustine is indicated for the treatment of patients with follicular lymphoma FL who did not respond or who progressed during or up to 6 months after treatment with rituximab or a rituximab-containing regimen. Obinutuzumab in combination with bendamustine is indicated for the treatment of patients with previously untreated advanced follicular lymphoma.

Obinutuzumab in combination with CVP chemotherapy is indicated for the treatment of patients with previously untreated advanced follicular lymphoma. Obinutuzumab in combination with CHOP chemotherapy is indicated for the treatment of patients with previously untreated advanced follicular lymphoma. As monotherapy for the treatment of adult patients with relapsed or refractory classical Hodgkin lymphoma cHL who are transplant-ineligible and have failed brentuximab vedotin. The benefit of pixantrone treatment has not been established in patients when used as fifth line or greater chemotherapy in patients who are refractory to last therapy.

Is indicated in combination with granulocyte-colony stimulating factor G-CSF to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in adult patients with lymphoma and multiple myeloma whose cells mobilise poorly.

As monotherapy for induction treatment for adult patients with stage III-IV follicular lymphoma who are chemoresistant or are in their second or subsequent relapse after chemotherapy. You might be interested in our animation video that explains how chemotherapy works. Chemotherapy drugs are also sometimes given with a different type of drug, such as an antibody therapy like rituximab , a targeted drug like ibrutinib , or a steroid such as prednisolone.

Sometimes, these other drugs are given without chemotherapy. There are lots of different chemotherapy regimens. Below, we list regimens that are most commonly used for lymphoma.

Using acronyms can make them easier to say. For some types of lymphoma, other drugs can be given together with chemotherapy. This is sometimes the case with:. Rituximab is usually used only for B-cell non-Hodgkin lymphomas.

ChlVPP — chl orambucil, v inblastine, p rocarbazine and p rednisolone. CVP — c yclophosphamide, v incristine and p rednisolone.

About 1 in 3 people with this type of lymphoma have chronic hepatitis C virus HCV infection. Treating the infection with anti-viral drugs can often cause these lymphomas to go into remission.

This can be very helpful in relieving symptoms if the spleen is enlarged. Treatment with rituximab may be another option. Another option might be a targeted drug such as ibrutinib Imbruvica or zanubrutinib Brukinsa , or rituximab with lenalidomide. Sometimes this lymphoma can transform into an aggressive large-cell lymphoma, which then requires more intensive chemo. This is a very fast-growing lymphoma that is similar to a type of acute lymphocytic leukemia. It is usually treated in the hospital with intensive chemo, which usually includes at least 5 chemo drugs.

Rituximab may also be added. Some examples of chemo regimens used for this lymphoma include:. Because this lymphoma tends to invade the area around the brain and spinal cord, the chemo drug methotrexate is often given into the spinal fluid called intrathecal therapy. This may not be needed if high-dose methotrexate is given as a part of the main chemotherapy regimen. An important part of the initial treatment of this disease is making sure a person gets plenty of fluids, as well as drugs like allopurinol, to help prevent tumor lysis syndrome described in Chemotherapy for Non-Hodgkin Lymphoma.

If the lymphoma goes into remission, the doctor might suggest a stem cell transplant. The main treatment for this lymphoma is usually chemo or rituximab. For more detailed information see Treating Waldenstrom Macroglobulinemia.

This is a slow-growing lymphoma that tends to invade the spleen and lymph nodes as well as the blood. When treatment is needed, most often the chemo drugs cladribine 2-CdA or pentostatin are used.

For more detailed information, see Treating Chronic Lymphocytic Leukemia. This lymphoma begins in the brain or spinal cord. It often develops in older people or those with immune system problems caused by AIDS or drugs given to keep transplanted organs from being rejected. For people in reasonably good health, high IV doses of the drug methotrexate have been shown to be the most effective treatment.

This is given along with the drug leucovorin and IV fluids, which help limit serious side effects. Other chemo drugs, such as cytarabine, may be added. Rituximab may be added as well. An issue with radiation therapy to the brain, especially in older patients, is that it can often cause mental changes. Doctors limit the dose of radiation to try to lessen this problem. If CNS lymphoma keeps growing or comes back after treatment, further options may include chemo using different drugs , radiation therapy, or a stem cell transplant if the person is healthy enough.

Most often doctors treat these cancers with radiation therapy, chemotherapy chemo , or a combination of the two. External beam radiation therapy is given if the cancer is limited to the eye. Radiation to both eyes may be recommended if lymphoma is found in both eyes.

Because these lymphomas are commonly linked with lymphoma of the brain CNS lymphoma , they have sometimes already spread outside the eye or to the brain when the cancer is first diagnosed. Problems with thinking, concentration, and memory are possible side effects from radiation to the brain and spinal cord.